National Centers for Translational Research in Reproduction and Infertility

Human Endometrial Tissue and DNA Bank

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University of California, San Francisco

PI: L. Giudice

The Human Endometrial Tissue and DNA Bank was established, under the direction of Dr. Giudice, in 1999 at the Stanford University SCCPIR Center, with the objective of acquiring, after written informed consent under an approved protocol, human endometrial tissue and DNA from well-characterized clinical subjects. The Bank moved to the University of California at San Francisco (UCSF) in October of 2005, when the Director and the Bank Coordinator moved to UCSF. The goal is for these well-characterized tissues to be available for use by participants in the NIH U54 Specialized Cooperative Centers Program in Reproductive Research (SCCPRR), now the Specialized Cooperative Centers Program in Reproduction and Infertility Research (SCCPIR). As of May 2011, 6,540 tissue samples from 910 subjects have been collected, processed, stored and/or distributed. Priority is given to SCCPIR investigators, and tissues are also made available to all NIH supported investigators in North America and NIH intramural investigators. The Bank is as a rich resource for collaborative research through the SCCPIR program and for pilot projects, including diagnostic and targeted therapeutic development. The tissues collected are used to investigate endometrial biology and mechanisms underlying endometrial receptivity to embryonic implantation. The specific aims are:

1. To identify and recruit human subjects to donate endometrium and DNA and to acquire, process, characterize, store, and distribute these specimens to SCCPIR participants for safe use in in vitro experiments.

2. To characterize endometrial tissue so that users have a complete database with regard to histology and important parameters, including subject menstrual, pharmacologic, fertility, pregnancy, and genetic history.

3. To maintain a database on human endometrial tissue specimens and DNA specimens that is secure, up to date, in compliance with human subjects protection, HIPAA, and accurate for interpretation of results.

University of California, San Francisco

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Center for the Origins and Biological Consequences of Infertility

Linda C. Giudice, M.D., Ph.D.
Distinguished Professor and Chair
The Robert B. Jaffe, M.D. Endowed Chair in
      the Reproductive Sciences
Department of Obstetrics, Gynecology and
      Reproductive Sciences
University of California, San Francisco
505 Parnassus Avenue
M1496, Box 0132
San Francisco, California  94143-0132
Phone: 415/476-2564
Fax:      415/476-6203


Recent Publications


Subprojects/Key Investigators

Mechanisms Controlling Oocyte Developmental Competence and Early Embryo Development
M. Conti

Molecular Analysis of the Early Stages of Human Trophoblast Differentiation
S. Fisher

Post-transcriptional Regulation of Trophoblast Differentiation
R. Blelloch

Development of Human Endometrium for Embryonic Implantation
L. Giudice

R. Rinaudo

Technical Service Cores/Directors

Computational Biology Research Core (closed)
J Song

Human Endometrial Tissue and DNA Bank (National Resource)
L. Giudice

Human Placental Bank
S. Fisher